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Collectively, these physicochemical and metabolic properties produce an absolute oral bioavailability estimated at less than 1% in most preclinical models ( The clinical implications of this pharmacokinetic deficit are substantial

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The multidisciplinary approach for the correction of this midface defect has appealed to clinicians to consider several key elements for the intervention and carry out surgical techniques, which would help bring out desired postoperative results

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10.1523/JNEUROSCI.1365-09.2009 Summary Keywords NMDA receptors, GluN2B, GSH metabolism, gamma-Glu-Glu, partial effect Citation Sebih F, Mokrane N, Fontanel P, Kayatekin M, Kaabeche M, Guiramand J, Cohen-Solal C, Cens T, Rousset M, Charnet P, De Jsus Ferreira M-C, Thibaud J-B, Mnard C, Cantel S, Rolland V, Vignes M and Roussel J (2022) The Glutathione Metabolite -Glutamyl-Glutamate Partially Activates Glutamate NMDA Receptors in Central Neurons With Higher Efficacy for GluN2B-Containing Receptors