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Physiology of GIP and GLP-1 in islet cells and the incretin effect The incretin effect is of major importance for normal glucose tolerance

The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade

This makes it an option in carefully selected paediatric and adolescent obesity cases, under specialist supervision