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Body weight did not increase from baseline with sitagliptin therapy in either trial, compared to a small reduction in patients given placebo

45 The second step is an irreversible rate-limiting reaction catalyzed by branched-chain -keto acid dehydrogenase (BCKDH), which is phosphorylated and inactivated by the specific kinase BCKDH kinase (BCKDK) and dephosphorylated and activated by Protein phosphatase 1 K (PPM1K)

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Insulin should never be stopped abruptly and should only be reduced stepwise with close monitoring

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