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Among these are neurodegenerative diseases, which are characterized by progressive neuronal impairment or loss leading to cognitive and motor decline ( Although direct evidence of CHAC1 involvement in human neurodegeneration remains limited, its well-established role in GSH catabolism positions it mechanistically at the intersection of ferroptotic pathways

10.22037/ijpr.2019.1100747 21 EyalS.YagenB.SobolE.AltschulerY.ShmuelM.BialerM

For example, ACC inhibitors are being explored for their potential to reduce lipogenesis and thus decrease fat accumulation in the liver and other tissues [12, 17, 19, 20]

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