As a publisher, our priority is to protect the validity of the scientific record, and, as with all our post-publication investigations, this determined our actions in this case, Chris Graf, research integrity director at Springer Nature, told Spectrum in an email
Grant: These are two good, but different, questions
The study investigators had final responsibility for the decision to submit the manuscript for publication
Microarray data analysis Microarray analysis was performed using control samples cultured for 4 or 6 days (n = 2), cataract samples cultured in galactose medium for 6 days (n = 3) and treated samples with glutamate addition (n = 2)
In few studies, the HMGCR mRNA levels in the liver increased after 4h of LPS treatment, which increased the hepatic cholesterol synthesis and serum cholesterol levels (101)