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Our study confirms more recent findings that opioid receptors are up-regulated in tissue in response to pain, particularly pain associated with inflammation. Ogru said a topical opioid product could eliminate the side effects associated with oral delivery and could be suitable for a number of hard-to-treat pain types such as diabetic neuropathy

The lack of highly effective treatments for many peripheral neuropathies creates clinical need for novel therapeutics

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According to clinical research parenteral administration (intramuscular or intravenous) is preferred over other drug administration routes in case of emergency situations as it provides first-pass metabolism avoidance, reliable therapeutic concentrations and better bioavailability of dosage (2) It can also be used in situations when oral route is not feasible

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