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While this potassium-sparing diuretic has classically been utilized in medicine as an antihypertensive agent, it has become increasingly employed by dermatologists for the treatment of oily skin, acne, hirsutism, and androgenic alopecia in women.[43,44] Spironolactone has been shown to directly reduce sebum production when dosed 50 to 200mg daily.[45] In addition to being an alderosterone antagonist, spironolactone also functions as an androgen receptor blocker and an inhibitor of 5alpha-reductase.[38] Human sebocytes contain Type 1 5alpha-reductase, which converts testosterone to the potent androgen 5alpha-dihydrotestosterone (DHT).[46] This androgen plays an important role in inducing sebocyte proliferation

doi: 10.1007/s11248-011-9534-6 150 Silva Rodrigues-CorraK.C.D.Fett-NetoA

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