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Nevertheless, ADA 2023 suggests that metformin's benefits on MACE remain potential and dubious [9], indicating that for patients with high risk of MACE, metformin combined with SGLT-2i or GLP-1 RAs with proven cardiovascular benefits may still contribute to the decrease of MACE risk

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Mingorance, C., Rodriguez-Rodriguez, R., Justo, M.L., Alvarez de Sotomayor, M