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Comment: Several commenters pointed to additional data sources separate from the RUC survey conducted for CPT code 64728

no human trial data exists

It focuses on gradual escalation of NAD dosage, mimicing cellular adaption, and the oral NR/NMN before the IV phase will help to prep NAD salvage pathways

2018, pp

Actomyosin contractility can compromise nuclear integrity by squeezing the nucleus dorsoventrally [191, 192], pulling it [193] or promoting the nuclear influx of cytoplasmic constituents, which in turn pressurizes the nucleus, leading to its rupture [155]