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According to the data provided by the Synapse Database, As of November 16, 2023, there are 303 investigational drugs for the GLP-1R and integrin target, including 72 indications, 276 R&D institutions involved, with related clinical trials reaching 2510, and as many as 7224 patents

These data reinforce the now well-documented role of ghrelin in food reward, considering that the shell region of the Acc is described to process unpredicted rewards and motivational states to reinforce food intake behaviors, but also use of drugs of abuse