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Kongwatcharapong J, et al

Clinical Efficacy: Macular degeneration risk reduction: 18-25% in high dietary intake groups Blue light filtering capacity: 40-90% depending on macular pigment density Digital eye strain improvement: Statistically significant in 2025 RCT (n=70) Contrast sensitivity enhancement: Demonstrated in multiple controlled trials Bioavailability Considerations: Lutein bioavailability from food sources ranges from 3-60%, influenced by food matrix, processing methods, and co-consumed lipids

NAION is a condition that can lead to vision loss resulting from damage to the optic nerve

Its mechanism NNMT inhibition leading to AMPK activation directly improves insulin sensitivity, as demonstrated in the 2021 Nature Metabolism study where treated mice showed reduced hepatic steatosis and improved glucose tolerance

These results suggested that IHPC alleviated chronic hypoxia-induced cognitive impairment and -syn pathology in mice