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Finally, we review mechanismbased strategiesincluding KRAS G12C inhibitors, effluxpump antagonists, apoptosis reactivators, and epigenetic/autophagy modulatorsand propose an integrated, multimodal regimen leveraging immunotherapy where appropriate, informed by real-time drug sensitivity data (e.g., from liquid biopsy), dynamic biomarkers and AIdriven optimization to overcome resistance and improve patient outcomes

Some clinicians avoid the DAC form for this reason, reserving it for patients who find daily injections prohibitive

AdamsJBAudhyaTMcDonough-MeansSRubinRAQuigDGeisEet al

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