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Early use of n-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction reduces myocardial infarct size (the NACIAM Trial [N-acetylcysteine in Acute Myocardial Infarction])

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However, conflicting evidence was presented by Goodman et al., showing that Smad3 gene transfer to skeletal muscle decreased miR-29 promoter activity, whereas Akt/mTOR activity was decreased and skeletal muscle atrophy was induced [139]

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