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The skin around our eyes is one of the most delicate areas of the face

Metabolic profiling Extraction and analysis of polar metabolites were performed as previously described 90,91 , with some modifications: 100 L of plasma were mixed with 1 mL of a pre-cooled (-20 C) homogenous methanol (MetOH):methyl-tert-butyl-ether (MTBE) 1:3 (v/v) mixture

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First is the urate-lowering agents allopurinol and febuxostat, which are traditional clinical agents used to inhibit xanthine oxidase and reduce uric acid levels