Causes of High Homocysteine Levels (Hyperhomocysteinemia) Many factors contribute to high homocysteine levels: Insufficient folate, vitamin B 6 , vitamin B 12 , betaine, vitamin B 2 , and magnesium Certain prescription drugs (including cholestyramine, colestipol, fenofibrate, levodopa, metformin, methotrexate, high-dose niacin, nitrous oxide, pemetrexed, phenytoin, sulfasalazine) High-methionine diet (including red meat and dairy products) Smoking High coffee consumption Alcohol consumption Advancing age Obesity Genetic variant that causes an impaired ability to metabolize active folate from folic acid Note: Life Extension believes that the optimal range for homocysteine levels is 11 mol/L) has been associated with a substantial increase in risk of dementia in the elderly
Cell 184 (8): 1945-1948
This pathway complements the B12/folate-dependent remethylation system and becomes especially crucial if that pathway is compromised, such as with an MTHFR gene mutation
And strength training can support weight loss goals by building lean muscle and reducing body fat, research shows
doi: 10.1097/01.mog.0000203870.22706.52 186
