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First of all, the defects downstream of insulin receptor phosphorylation, such as activation of phosphorylated IRS-1 through PKC or GLUT-4 translocation through PI3K/Akt signaling pathway, are the causes of IR in some PCOS women

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Can be used as monotherapy or in combination with other diabetes medications including metformin, sulfonylureas, SGLT2 inhibitors, and insulin

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