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Proinflammatory cytokines such as Tumor Necrosis Factor (TNF)-, interleukin (IL)-1 or IL-18 induce the endocytosis of epithelial apical junctional proteins [120], promoting an increment in intestinal permeability [121]

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Ren W, Wang W, Guo Y

Consequently, the synthesis of proteoglycans is reduced, accompanied by the conversion of collagen synthesis, in which type II collagen is reduced and type I and type III collagen are increased (Fig