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Calculation of the actual potential in biological samples from concentration measurements is further complicated by vague estimations of subcellular compartment volumes and artifacts occurring during sample work-up
Given that there may be similar immune mechanisms responsible that underpin both tumour control and irAEs, researchers were concerned initially that steroids or other immunosuppressive agents to control irAEs would also hinder tumour control
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Researchers also noted that participants who discontinued treatment after a sustained period began to regain weight during follow-up, reinforcing that Mounjaro works best as part of an ongoing, medically guided treatment plan rather than a short-term course
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