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In rodents, activation of AMPA receptors by the KET metabolite (2R,6R)-hydroxynorketamine has initially been thought essential to replicate KET antidepressant effects while administration of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX), an AMPA receptor antagonist, blocks KET effects (Zanos et al., 2016)

Specialist weight management services may prescribe higher-dose semaglutide (Wegovy) for adults with a BMI 35 kg/m (or 30 kg/m in exceptional cases) and at least one weight-related comorbidity

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