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Many clinical studies have shown abnormalities within the cerebrospinal fluid and serum of patients with FMS versus healthy controls, the most dramatic of which were increased cerebrospinal fluid levels of substance P and decreased serum serotonin levels.14-16 Most antidepressant medications raise levels of serotonin by various mechanisms (selective serotonin re-uptake inhibitors, monoamine oxidase inhibitors), providing one plausible explanation of why low doses of these drugs help some patients with FMS

The role of the gut microbiota in nutrition and health

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The cold environment inhibits hydrolysis, oxidation, and deamidation reactions that would otherwise destroy peptide bonds and biological activity