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The researchers utilized data from the Kuopio Ischaemic Heart Disease Risk Factor study to examine the relationship between MetS and cardiovascular mortality (40)

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The decrease in circulating melatonin levels over the course of a persons lifetime, which coincides with a more general decline in many circadian rhythms as people get older, is a compelling indicator that melatonin, even at physiological levels, may have an important role to play in this process