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AGE advanced glycation end products APCs antigen-presenting cells CAPCs circulating angiogenic progenitor cells CVD cardiovascular diseases DCs dendritic cells ECs endothelial cells EMPs endothelial microparticles ER endoplasmic reticulum FFAs free fatty acids GLUT glucose transporter HDLs high-density lipoproteins HN humanin HUVECs human umbilical vein endothelial cells IAPP Islet amyloid polypeptide IECs intestinal epithelial cells IFN Interferon IL interleukin MGO methylglyoxal MP microparticle NETs Neutrophil Extracellular Traps NKs Natural killer cells NLRP3 nucleotide-binding oligomerization domain, leucine-richcontaining family, pyrin domain-containing 3 Ox-LDL Oxidized low-density lipoprotein PPAR peroxisome proliferator-activated receptors ROS reactive oxygen species sdLDL small dense LDL TG triglyceride T2DM type 2 diabetes mellitus TNF- tumor necrosis factor-alpha UTIs urinary tract infections

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Hormonal and blood-sugar disruption, including elevated cortisol and prolactin, reduced insulin sensitivity, and hypoglycemia risk tied to IGF-1 receptor activity

It is available in certain clinics under compounding programs, but quality and consistency can vary widely depending on the source (FDA PCAC briefingcompounding context)