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This process is governed by BCL2 family proteins, including the pro-apoptotic BCL2 associated X, apoptosis regulator (BAX) or BCL2 antagonist/killer 1 (BAK1, also known as BAK) as well as anti-apoptotic members, such as BCL2 apoptosis regulator (BCL2) and BCL2 like 1 (BCL2L1, also known as BCL-XL)

doi: 10.3390/molecules28062536 122 Nagasako-AkazomeY

followed by an overview of the complex pathophysiology and management of the condition

Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin

see Additional file 8 for the GSEA enrichment plot and Additional file 1 for the fibroblast culture methods)