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For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures

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In the primary analysis, we identified self-harm by using hospital admission events, thus restricting it to the most serious events to maximise the specificity of the outcome definition, but leading to the possibility of outcome misclassification