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Surgery Is a One-Time Treatment Gastric sleeve, bypass, and SADI involve upfront cost and recovery, but the metabolic effect can last for years when paired with healthy habits

Buhling F, Junker U, Reinhold D, Neubert K, Jager L, Ansorge S

Your clinician can advise whether a trial of an alternative agent is appropriate

PMCID: PMC11328632 Sun Y, Chen J, Shi X et al (2024) Safety and efficacy of melatonin supplementation as an add-on treatment for infantile epileptic spasms syndrome: A randomized, placebo-controlled, double-blind trial

ROS and RNS may trigger programmed cell death, e.g., apoptosis [29], necessary for tissue remodeling during the development and normal tissue turnover [30], proliferation, differentiation, maturation of neural stem cells, dendritic processes, and synaptic plasticity [31,32,33]