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[6] Artesunate was developed by Liu Xu in 1977

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10.1007/s10792-019-01129-1 79 LiuX.ZhangY.ZhuangL.OlszewskiK.GanB

Emerging evidence further indicates that MTs particularly MT1 and MT2A constitute a critical cytoplasmic defense layer against cuproptosis by acting as effective copper sponges that sequester excess Cu + and restrict its aberrant interaction with mitochondrial targets 170,173,174

Similar results were observed when tumours were implanted into the flanks of mice, a result that suggests that this phenotype is not specific to the mammary gland environment (Extended Data Fig