A New Era for Diabetes Care The NTU teams research reflects a broader shift towards precision medicine, tailoring treatments to each patients unique health profileconsidering factors like kidney function, cardiovascular risk, and overall health status
At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]
It typically improves over time, but the early weeks of treatment can make eating feel genuinely difficult
Sabrina C
Billings presented the latest data at EASD 2024, which showed that IcoSema led to similar A1C reductions and greater weight loss with less severe hypoglycemic episodes compared to daily basal-bolus insulin