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Phase 1a studies in healthy volunteers, published in Diabetes, Obesity and Metabolism in 2023, established the compound's single-dose and multiple-dose pharmacokinetics, confirming a half-life supportive of once-daily dosing, a favorable food-effect profile, and dose-proportional exposure across the tested range

Research in cell culture and rodent models consistently demonstrates that MOTS-c accelerates this translocation independently of insulin, offering a distinct and additive mechanism to insulin sensitizers like Metformin [1]

Does the composition of gut microbiota affect chronic kidney disease

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