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Rybelsus demonstrated 44% greater A1c reduction than the placebo

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Expression of carnitine palmitoyltransferase 1A (CPT1a) and of carnitine-acylcarnitine translocase (CACT or SLC25A20), enzymes critical for the transfer of long-chain FA through the outer and inner mitochondrial membranes, respectively, were substantially reduced in the kidneys of cKOt mice (Figure 5)

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