Kwun IS, Cho YE, Lomeda RR, Shin HI, Choi JY, Kang YH, et al
Patients with polycythemia vera a blood disorder involving overproduction of red blood cells face additional risks since B12 stimulates red blood cell production
Still, this does not preclude extramitochondrial CHAC1 from concurrently influencing ferroptosis, as we show that CHAC1 loss significantly spares cytosolic GSH under cystine starvation, a significant factor in the capacity of cells to mitigate lipid peroxidation 11
Additionally, global warming is increasing the water stress in vines due to lower rainfall in many regions especially during the fruit growth and increasing pests and diseases (Jones and Alves, 2012
7ad), even though it promoted the accumulation of GSH in cells (Extended Data Fig