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The brain is vulnerable to increased ROS due to its high metabolic rate and relatively low antioxidant defense ability

A review Behav Brain Res 285:105117

Figure 3 Fatty acid biosynthesis requires substantial NADPH, which, in oleaginous fungi like Rhodosporidium toruloides and Mucor circinelloides , is often supplied by malic enzyme (ME) (Ratledge, 2014)

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