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doi: 10.3389/fphar.2025.1516601 Received 24 October 2024 Accepted 04 February 2025 Published 24 February 2025 Volume 16 - 2025 Edited by Ewa Litwa, Polish Academy of Sciences, Poland Reviewed by Stefano Comai, University of Padua, Italy Archita Venugopal Menon, Beam Therapeutics, United States Updates Copyright 2025 Zhao, Ren, Luo, Li, Cheng, Wen, Wu and Zhou

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A central objective of pro-oxidant therapeutic strategies is to trigger ferroptosis a distinct, iron-dependent form of regulated cell death characterized by excessive lipid peroxidation