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Safety in these populations cannot be assumed based on the existing trial data

When weight drops through calorie restriction alone, a significant portion of that loss often comes from lean tissue Hormone Imbalance Treatment: Why Everything Feels Off And What To Do About It Hormone imbalance treatment begins with understanding that hormones do not operate in isolation

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[2] However, elevated MMA is not conclusive, as it is seen in people with B 12 deficiency, but also in elderly people who have renal insufficiency, [28] and elevated homocysteine is not conclusive, as it is also seen in people with folate deficiency

Many approaches to weight loss, including severe caloric restriction and even some GLP-1 medications, can lead to substantial loss of lean tissue along with fat