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A molecule that binds IGFBPs poorly gains free-ligand availability at any given moment but forfeits the reservoir that would otherwise keep it in circulation so more active per molecule and present in the body longer are not the same property, and the second does not automatically follow from the first

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Perineurial cell basement membrane thickening and myelinated nerve fibre loss in diabetic and nondiabetic peripheral nerve

This can help keep your blood sugar levels more stable

It plays a critical role in detoxifying harmful substances and protecting cells from oxidative stress