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This inflammatory burden contributes not only to insulin resistance but also to pain sensitization

A rigorous LOE model for any pharmaceutical asset should incorporate seven input variables: the projected expiration of each Orange Book-listed patent, the survival probability of each patent under IPR challenge, the number and quality of ANDA filers identified in FDA ANDA filing databases, the probability and likely terms of any patent litigation settlement, the applicable FDA regulatory exclusivity periods, any REMS-related barriers that could delay generic development, and the manufacturing complexity of the drug, particularly for complex dosage forms or biologics

V., Malnic, G

This means keeping an eye on any unusual symptoms or changes in health

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