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Gastrointestinal Research Highlights Intestinal permeability: BPC-157 has been shown to stabilize intestinal permeability and enhance cytoprotective mechanisms, rescuing NSAID-induced cytotoxicity in preclinical models (Park et al., 2020, Curr Pharm Des )

3.1 Regulation of immune cell function 3.1.1 T cell In RA, immune cells function abnormally, producing a large number of inflammatory factors, such as tumor necrosis factor (TNF)-, interleukin (IL)-6, and IL-17, which are distributed in clusters in the diseased joints, causing an inflammatory storm (5759)