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Ms all de la Semaglutida, otros 4 medicamentos, y combinaciones de medicamentos, estn aprobados para el control crnico del peso en los Estados Unidos: Liraglutida (Saxenda) Orlistat (Alli y Xenical) Naltrexona + bupropin (Contrave) Fentermina + topiramato (Qsymia) Introducida en 1959, la fentermina es el medicamento recetado para la obesidad ms antiguo aprobado por la FDA y, segn un informe del gobierno de 2019, el medicamento para bajar de peso ms recetado en los Estados Unidos

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Figure 3 shows the cumulative incidences of colorectal cancer and liver cancer comparing GLP-1RAs with insulins