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Presumably, specifically inhibiting the binding between CXCL10 and IL18R1 could rescue ovarian damage without affecting its normal function in other tissues

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Nevertheless, these co-agonists must be carefully monitored as a loss in GLP-1R activity could lead to excessive glucagon-mediated deleterious effects on glucose control

Although an association with urinary congenital malformations was identified, it was based on limited unadjusted data and may reflect confounding by maternal diabetes or obesity rather than a true treatment effect