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[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Huang C., Wu J., Chen D., Jin J., Wu Y., Chen Z

The reasons for Pure PRPs superior comfort profile include: Neutrophils in Regular PRP release inflammatory cytokines (TNF-, IL-1, IL-6) that prolong inflammation and increase pain[8][10] Red blood cells create viscosity in Regular PRP that makes injections more painful and traumatic[1][7] Hemoglobin release from damaged red blood cells causes tissue damage and oxidative stress[7] Pure PRPs cellular purity eliminates these pain-causing components entirely 2

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Food Chem Toxicol 41:265273

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