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That pressure, combined with relaxed lower esophageal tone (another GLP-1 effect observed in animal models), makes reflux and belching more likely regardless of food content

For most individuals, the itchiness is localized and temporary, but for others, it may signal a need to adjust the treatment plan or consult a healthcare provider

There is no consensus on which dietary approach is best

Instead, they start to prefer more filling, protein-rich meals

A phase II trial focusing on individuals with overweight or obesity, coupled with hypertension or dyslipidemia but without T2D, found that cagrilintide (2.4 mg) alongside diet and exercise, led to a 10% body weight reduction compared to 3% with placebo over 26 weeks [99]