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Prolonged treatment with DMF in a human oligodendrocyte cell line elicited increases in both succinate and fumarate (44)

approved final version of manuscript

Because the process for requesting or granting an ECE will remain the same as the current ECE process, these updates will not affect burden associated with the submission of the ECE form

The study results revealed that the Imiquimod loaded polymeric nanoparticles showed greater efficacy against tumors followed by the marketed Imiquimod formulation and placebo showing the enhanced effectiveness of the Nano formulation approach over the conventional formulation of Imiquimod [249]

Blood sugar levels, kidney function, and any signs of pancreatitis should be monitored