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Platt TL, Beckett TL, Kohler K et al (2016) Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease

As mitochondrial function declines over time, people often experience: Sarcopenia (muscle loss) Weight gain Reduced energy Brain fog Insulin resistance Chronic inflammation Reduced athletic capacity Slower recovery Fatigue Hormonal imbalance Scientists believe mitochondrial dysfunction is one of the core hallmarks of aging

Many peptide programs use injections, but routes and protocols vary

For very high disease activity, you may even go right to an IL-17 blocker and bypass anti-TNFs, which have not proven as effective for ankylosing spondylitis as they have been for other types of inflammatory arthritis

For these reasons, precursors of GSH have been investigated