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The potential of this study to provide proof-of-concept (PoC) for the use of CT-996 in the treatment of obesity at Phase 1 is limited, given that Phase 1 studies are primarily designed to assess the safety and tolerability of a drug, rather than its efficacy in treating a particular condition

One unexpected serious adverse reaction occurred in a NAC-treated patient caused by an erroneous iv infusion rate (1.5g-loading dose-15 min followed by 7.5 g delivered over 3h15min instead of 4 h), causing chest tightness, despite stable vital signs, which was resolved by corticosteroids and discontinuation of iv NAC

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such formulation has addressed the issues with low oral bioavailability of luteolin [278]