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From a physicochemical point of view, pharmacologically active cannabinoids are classified as Class II, according to the Biopharmaceutics Classification System (BCS) for oral drugs, as they have very low water solubility and high lipophilicity

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We hypothesized that early Akk11 supplementation enhances the metabolic benefits of GLP-1RA by remodeling gut microbiota composition, promoting GLP-1R signaling, and ultimately alleviating hepatic steatosis

DOI: 10.1111/j.1473-2165.2011.00570.x