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The primary outcomes of the study were decreases in SOD activity, IL-1 mRNA, and concentrations of MDA, H 2 O 2 , IL-4, IL-8, and IL-10 in circulation over time

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This is why stopping the medication during the early adjustment period (often the first month or two), when side effects are at their worst, often means missing the window in which the body would naturally adapt

Elsevier, Amsterdam, pp 326362 Maselli J, Hales BF, Chan P, Robaire B (2012) Exposure to bleomycin, etoposide, and cis-platinum alters rat sperm chromatin integrity and sperm head protein profile1

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