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Key points Methotrexate is a key component in the treatment of inflammatory rheumatic diseases and the mainstay of therapy in rheumatoid arthritis

They can be locally acting, and in the event of an adverse reaction, they are rapidly cleared, reducing systemic exposure

Every PPS Lead partner is required to submit an attestation statement documenting that each partner included in its Network Tool partner list has formally consented to be part of the PPS

UVB primarily targets the epidermis, inducing acute inflammation, keratinocyte proliferation, significant melanocyte activation and morphological changes 10,11

Starting at 3% or higher virtually guarantees some level of irritation for most users