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doi: 10.1097/TA.0b013e31827e1f51
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Greater Safety for At-Risk Populations Sodium Chloride Injection is generally the preferred option for: Neonates and infants Pregnant or breastfeeding individuals Patients with known preservative sensitivities Considerations When Using Sodium Chloride Injection While widely used, Sodium Chloride Injection should be administered with caution in certain clinical contexts
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Future studies demonstrated that KEAP1 does not passively sequester NRF2 in the cytosol, but actively functions as a ubiquitin ligase, leading to ubiquitination and proteasomal degradation of NRF2 (Zhang and Hannink, 2003)
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