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Additionally, many users suggest pairing the treatment with exercise and lifestyle modifications

48 Intrahypothalamic or intraventricular administration of insulin slows food intake and creates a sustained loss of body weight in both rodents 49 and acts as a meal initiation signal

The 7.2 mg option is relevant for patients who plateau on standard dosing and whose providers determine the higher dose is clinically appropriate

Clinical Implications for Efficacy and Side Effects The possibility that gastric motility adapts during GLP-1 therapy raises important clinical considerations