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a method for additional weight management in a subject in need thereof with a BMI 27 kg/m 2 and at least one weight-related comorbidity comprising: administer to said subject 2.5 mg once weekly tirzepatide dose, or a pharmaceutically acceptable salt thereof

86,87 Modic change-like changes were also reported after perforation of the endplates in a pig model: oedema, fibrosis, and inflammatory cell infiltration into the bone marrow around the endplate defect were seen

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This would be representative generally of a comprehensive county run county contracted system capable of managing large volumes of uninsured patients