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Compared with conventional GLP-1 receptor agonists, such as liraglutide and semaglutide, tirzepatide has demonstrated superior efficacy in body weight control in several phase III clinical trials, with average weight reductions exceeding 20% in some study populations (15)

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In older adults, the preservation of functional capacity and independence, as well as the prevention of frailty and sarcopenia, depends critically on maintaining adequate muscle (especially skeletal) mass and quality